Trifluoroacetic Acid Hydroxylamine System as Organocatalyst Reagent in a One-Pot Salt Free Process for the Synthesis of Caprolactam and Amides of Industrial Interest

Abstract In this work we studied the reactivity of Trifluoroacetic acid hydroxylamine system in one step salt free synthesis amides from ketones. A particular regards was paid to caprolactam because its industrial relevance. Synthesis, and characterization trifluoroacetate is given. Fast oximation reaction several ketones gained at room temperature (1 h quantitative conversion for ketones). same reactor, by raising 383 K, Beckmann rearrangement so obtained oximes easily accomplished presence three equivalent TFA. The possibility obtaining with a modified nitric hydrogenation reactions verified, too. Reuse solvent trifluoroacetic achieved distillation. Graphical abstract Salt one-pot process catalyzed CF 3 COOH, NH 2 OH TFA as agent.